Showing posts with label environment. Show all posts

12 Years Later: Environmental Causes of Autism Still Unexplored

"The Environment as an etiologic factor in autism: a new direction for research"  by EA London was published online by ehp, Environmental Health Perspectives, in 2000. Today, 12 years later, it remains the direction not taken as "autism research" continues down the road of genetic obsession and largely ignores environmental autism research.

Although public health authorities have paid lip service to the idea that autism appears to result from gene environment interaction funding has been overwhelmingly directed towards the gene side of the equation. The people who are much smarter than most of us, who understand things we can not possibly understand, who do not need our input as unwashed, unthinking parents of autistic children simply keep on keepin' on with their religious like belief that autism is primarily genetic.  Following is the abstract and the suggestion for new lines of investigation into environmental exposures which the US IACC, the Canadian Institutes for Health Research and other agencies involved with setting directions for autism research do not appear to have accepted. Of course the genetic obsession research has brought us a better understanding of autism causes .... hasn't it?

Abstract

Autism is one of a group of developmental disorders that have devastating lifelong effects on its victims. Despite the severity of the disease and the fact that it is relatively common (15 in 10,000), there is still little understanding of its etiology. Although believed to be highly genetic, no abnormal genes have been found. Recent findings in autism and in related disorders point to the possibility that the disease is caused by a gene-environment interaction. Epidemiologic studies indicate that the number of cases of autism is increasing dramatically each year. It is not clear whether this is due to a real increase in the disease or whether this is an artifact of ascertainment. A new theory regarding the etiology of autism suggests that it may be a disease of very early fetal development (approximately day 20-24 of gestation). This theory has initiated new lines of investigation into developmental genes. Environmental exposures during pregnancy could cause or contribute to autism based on the neurobiology of these genes.

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NIMH Director Thomas Insel: Study Finding Environmental Role in Autism in Line with Other Recent Observations

"These new findings are in line with other recent observations supporting both environmental and genetic contributions to ASD, with the environmental factors likely prenatal and the genetic factors highly complex and sometimes not inherited" 


NIMH director Thomas R. Insel, M.D. 


The recent twins study led by Dr. Joachim Hallmayer and Neil Risch, Ph.D., has grabbed the attention of the world's media and shaken the "autism is genetic" mindset that has dominated autism research for many years.  The reaction to the study by the autism is primarily genetic research establishment has been quick and fearful. Within just a few days attempts were underway to diminish the study design and the outcomes of the study.  Portraying the study as controversial when it is anything but is the most obvious sign of desperation by the autism is genetic establishment. 

Such efforts should be taken with a huge grain of salt and the words of Dr. Insel remembered: the autism twins study results are "in line with other recent observations supporting both environmental and genetic contributions to ASD, with the environmental factors likely prenatal and the genetic factors highly complex and sometimes not inherited."

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Autism & Environment Study:Genetics Only Autism Gang Running Scared, Creates Faux Controversy

Scared by althetrainer

The "it's gotta be genetic" gang is running scared over the recent twins study which confirms the pardigm shift in autism causation from 100% genetic to a gene-environment interaction model and which places much greater emphasis on the role of environmental factors, particularly perinatal and prenatal factors in triggering autism disorders.   The ink is barely dry on the paper and already  an article has appeared online at "Science" News with the headline and sub headline:  Environment blamed for autism Controversial twin study challenges idea that genes determine autism risk.

Where is the controversy?  Under the guise of science ScienceNews is helping create controversy by describing the study as controversial.  Teresa Binstock was right many years ago when she described the thinking of the public health research establishment as fixated on the view that autism has to be genetic. That view has been eroded over the last half decade by an autism paradigm shift which views autism as resulting from gene environment interaction.  The failure of the overwhelmingly genetic oriented autism research of the past decade to provide a clear genetic basis for autism causation preceded the recent studies which assign more responsibility for autism causation to environmental factors.  The "it's gotta be genetic" autism crowd is running skeeeeered. 

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